Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes

PHASE2CompletedINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

January 1, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2023

Conditions
SepsisLymphocyte Disorder TImmunologic ParalysisCatecholamine; OverproductionBeta-BlockerCytokine StormSympathetic Nervous System Diseases
Interventions
DRUG

esmolol

The primary intervention is the administration of Esmolol. Esmolol was specifically used to evaluate its immunomodulatory effects in patients with sepsis in the study. The dosage was tailored to achieve optimal heart rate control, an integral part of the therapeutic strategy aiming to mitigate the hyperadrenergic state often seen in sepsis. Alongside Esmolol, daily electrocardiogram (ECG) monitoring was incorporated to observe any changes in the QT interval, ensuring cardiac safety due to the known potential cardiac effects of beta-blockers.

Trial Locations (1)

610091

Sichuan Provincial People's Hospital, Chengdu

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Lin Chen

OTHER