RC48 Combined With Adebrelimab, Apatinib and S-1 as Neoadjuvant Therapy in Locally Advanced Gastric Cancer

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

May 1, 2024

Primary Completion Date

May 1, 2027

Study Completion Date

May 1, 2028

Conditions
Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
Interventions
DRUG

RC48

RC48: 2.5 mg/kg, intravenous infusion, on day 1, every 3 weeks (Q3W);

DRUG

Adebrelimab

Adebrelimab:1200 mg, intravenous infusion, on day 1, every 3 weeks (Q3W);

DRUG

Apatinib

Apatinib: 250mg, oral administration, once daily (qd), every 3 weeks (Q3W);

DRUG

S-1

S-1:For patients with a body surface area (BSA) ≤1.5m², use 50mg each time; for patients with BSA \>1.5m², use 60mg each time, oral administration, twice daily (bid), on days 1-14, every 3 weeks (Q3W);

All Listed Sponsors
lead

The First Affiliated Hospital with Nanjing Medical University

OTHER

NCT06385873 - RC48 Combined With Adebrelimab, Apatinib and S-1 as Neoadjuvant Therapy in Locally Advanced Gastric Cancer | Biotech Hunter | Biotech Hunter