A Study of BV-AVD in People With Bulky Hodgkin Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

71

Participants

Timeline

Start Date

April 17, 2024

Primary Completion Date

April 30, 2027

Study Completion Date

April 30, 2027

Conditions
Hodgkin Lymphoma
Interventions
DRUG

Brentuximab vedotin

Brentuximab vedotin will be administered at 1.2 mg/kg IV on days 1 and 15 of each 28-day cycle

DRUG

Doxorubicin

Doxorubicin 25 mg/m\^2 IV

DRUG

Vinblastine

Vinblastine 6 mg/m\^2 IV

DRUG

Dacarbazine

Dacarbazine 375 mg/m\^2 IV on days 1 and 15 of each 28-day cycle

DRUG

Pembrolizumab

Pembrolizumab will be administered at 200 mg IV (flat) on day 1

DRUG

Gemcitabine

Gemcitabine 1000 mg/m\^2 IV (days 1 an

DRUG

Vinorelbine

Vinblastine 6 mg/m\^2 IV

DIAGNOSTIC_TEST

FDG-PET/CT scan

After 2 cycles of therapy, patients will undergo FDG-PET/CT scan

Trial Locations (8)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

10604

RECRUITING

Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale

11725

RECRUITING

Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities), Commack

33136

NOT_YET_RECRUITING

University of Miami, Miami

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth (All Protocol Activities), Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen (All Protocol Activities), Montvale

All Listed Sponsors
collaborator

Seagen Inc.

INDUSTRY

lead

Memorial Sloan Kettering Cancer Center

OTHER