Evaluating the Human Immune Response to the JYNNEOS Vaccine

EARLY_PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 10, 2024

Primary Completion Date

September 30, 2026

Study Completion Date

December 31, 2026

Conditions
VacciniaVirus Diseases
Interventions
BIOLOGICAL

JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection

live, nonreplicating vaccine delivered according to the FDA approved package insert

PROCEDURE

Phlebotomy

Research blood draw

PROCEDURE

Research bronchoscopy

Outpatient research bronchoscopy with bronchoalveolar lavage and endobronchial biopsy performed with conscious sedation.

PROCEDURE

Skin punch biopsy

Skin punch biopsy performed with topical anesthesia.

PROCEDURE

Bone marrow aspiration

Bone marrow aspiration performed with local anesthesia.

Trial Locations (1)

63110

Washington University in Saint Louis School of Medicine Emergency Care and Research Core, St Louis

All Listed Sponsors
lead

Washington University School of Medicine

OTHER