Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

April 15, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

June 30, 2028

Conditions
cGVHD
Interventions
DRUG

anti-CD25 rhMAb

1 mg/kg/day administered IV day 1, 4, and 8, then weekly for 6 doses. For patients achieving partial remission, an extra dose of Anti-CD25 rhMAb can be given on days 39 and 49.

DRUG

Prednisone

Maintain pre-screening dose

DRUG

Ruxolitinib

10mg, BID PO

DRUG

Cyclosporine

1.25mg/kg, BID PO/IV, target:150-250ng/ml

All Listed Sponsors
lead

Peking University People's Hospital

OTHER

NCT06364319 - Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD | Biotech Hunter | Biotech Hunter