Natural History Study of Children With LAMA2-related Dystrophies

RecruitingOBSERVATIONAL
Enrollment

40

Participants

Timeline

Start Date

December 5, 2024

Primary Completion Date

December 4, 2027

Study Completion Date

December 31, 2027

Conditions
Merosin Deficient Congenital Muscular Dystrophy
Interventions
OTHER

Motor evaluations

Evaluation of patients motor function using motor scales (MFM32, RULM), Timed functioned tests (6MWT, Rise from floor, 4SCT, 10mWT), dynamometric strength evaluation (grip, pinch, flexion/extension)

OTHER

Cognitive assessment

Patients cognitive evaluation (WPPSI-IV, WISC-V)

OTHER

Pulmonary function test

Evaluation of patients' respiratory function (FVC, PCF, MIP, MEP, SNIP)

OTHER

Cardiac evaluation

Evaluation of patients' cardiac function (ECG, Echo-cardiography)

OTHER

Quality of life

Evaluation of patients quality of life with questionnaires and PROM

OTHER

Spine X Ray

Evaluation of spinal deformities by X-ray

OTHER

Muscular MRI

Evaluation of a qualitative whole-body muscle part and a quantitative lower limb muscle part by MRI

OTHER

Biomarkers collection and analysis

Collection of blood and urinary sample for biomarkers research.

Trial Locations (4)

Unknown

NOT_YET_RECRUITING

Centre de Référence GNMH, Pédiatrie Hôpital Raymond-Poincaré, Garches

NOT_YET_RECRUITING

Service de MPR pédiatrique L'Escale - HCL, Lyon

NOT_YET_RECRUITING

Département de neuropédiatrie Pôle Femme Mère Enfant CHU de Montpellier - Hôpital Gui de Chauliac, Montpellier

RECRUITING

Plateforme d'essais cliniques pédiatriques iMotion, Paris

All Listed Sponsors
collaborator

Association Française contre les Myopathies (AFM), Paris

OTHER

lead

Institut de Myologie, France

OTHER