Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY)

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

162

Participants

Timeline

Start Date

February 1, 2025

Primary Completion Date

February 1, 2028

Study Completion Date

February 1, 2028

Conditions
Liver TransplantationImmunosuppression
Interventions
DRUG

XR-tacrolimus QD + MMF BID then MMF QD

Patients start on XR-Tacrolimus once daily (QD) and MMF twice daily (BID) as per the usual care. At 6 months post-transplantation (±1 month) MMF administration frequency will be switched from BID to QD, in the morning, at the same daily dose

DRUG

XR-tacrolimus QD + MMF BID

Patients receive XR-tacrolimus once daily (QD) and MMF twice daily (BID) as per the usual care.

DRUG

LCP-tacrolimus QD + MMF QD then MMF QD

Patients start on LCP-Tacrolimus once daily (QD) and MMF twice daily (BID) as per usual care. At 6 months post-transplantation (±1 month), MMF administration frequency will be switched from BID to QD, in the morning, at the same daily dose

DRUG

LCP-tacrolimus QD + MMF BID

Patients receive LCP-tacrolimus once daily (QD) and MMF twice daily (BID) as per the usual care.

Trial Locations (15)

13000

APHP, Marseille

31000

Toulouse university hospital, Toulouse

33604

Bordeaux university hospital, Pessac

34000

Montpellier university hospital, Montpellier

35033

Rennes university hospital, Rennes

37000

Tours university Hospital, Tours

59000

Lille university hospital, Lille

67000

Strasbourg university hospital, Strasbourg

69000

Lyon university hospital, Lyon

75013

Pitie Salpetriere hospital - APHP, Paris

86000

Poitiers university hospital, Poitiers

87042

Limoges university hospital, Limoges

92110

Beaujon hospital - APHP, Clichy

94800

Paul Brousse Hospital - APHP, Villejuif

06202

Nice university hospital, Nice

All Listed Sponsors
lead

University Hospital, Limoges

OTHER