Neoadjuvant IMRT Combined With Camrelizumab and Apatinib for Resectable HCC With PVTT

PHASE2RecruitingINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

April 22, 2024

Primary Completion Date

May 31, 2026

Study Completion Date

June 30, 2026

Conditions
Hepatocellular Carcinoma
Interventions
COMBINATION_PRODUCT

Neoadjuvant intensity-modulated radiotherapy combined with perioperative camrelizumab and apatinib

"1. Preoperative IMRT targeting PVTT and intrahepatic tumor lesions with a prescribed dose for 18Gy in 6 fractions delivered by using 6-MV X-rays with a linear accelerator at 5 fractions per week;~2. Perioperative combination of camrelizumab and apatinib Preoperatively, camrelizumab (200mg, every 2 weeks) combined with apatinib (250mg, daily) for 2 cycles (2 weeks as one cycle); Postoperatively, camrelizumab (200mg, every 3 weeks) combined with apatinib (250mg, daily) for 8 cycles (3 weeks as one cycle)."

Trial Locations (1)

Unknown

RECRUITING

Mengchao Hepatobiliary Hospital, Fujian Medical University, Fuzhou

All Listed Sponsors
lead

Yongyi Zeng

OTHER