Cessation of Somatostatin Analogues After PRRT in Mid, Hind-Gut and Pancreatic Neuroendocrine Tumours

PHASE2RecruitingINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

October 14, 2024

Primary Completion Date

September 30, 2027

Study Completion Date

June 30, 2028

Conditions
Neuroendocrine Tumors
Interventions
DRUG

Cessation of somatostatin analogues

Patients randomised to cease SSA will receive their last SSA injection ≥28 days prior to their first cycle of PRRT and will remain off SSA for the duration of the study. If there is concern from the treating team that a patient may experience a carcinoid flare after PRRT, then short acting octreotide is allowed to be used to control any symptoms.

DRUG

Continuation of somatostatin analogues

Patients randomised to continue SSA will receive a SSA injection ≥28 days prior to their first cycle of PRRT, during PRRT and will continue receiving SSA every 4 weeks after PRRT.

Trial Locations (12)

2065

RECRUITING

Royal North Shore Hospital, Sydney

2502

RECRUITING

Wollongong Hospital, Wollongong

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

4006

RECRUITING

Royal Brisbane and Womens Hospital, Brisbane

5000

RECRUITING

The Queen Elizabeth Hospital, Adelaide

6150

RECRUITING

Fiona Stanley Hospital, Perth

V5Z 4E6

RECRUITING

BC Cancer Agency, Vancouver Cancer Centre, Vancouver

N6A 5W9

RECRUITING

London Health Sciences Centre Research Institute (LHSCRI), London

K1Y 1J8

RECRUITING

Ottawa Hospital Research Institute, Ottawa

TG 260

RECRUITING

Odette Cancer Centre Sunnybrook Health Sciences Centre, Toronto

S4T 7T1

RECRUITING

Allan Blair Cancer Centre, Regina

S7N 4H

RECRUITING

Saskatoon Cancer Centre, Saskatoon

All Listed Sponsors
collaborator

Canadian Cancer Trials Group

NETWORK

lead

Australasian Gastro-Intestinal Trials Group

NETWORK