NCT06337838View on ClinicalTrials.gov

Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

June 9, 2025

Primary Completion Date

February 28, 2027

Study Completion Date

June 30, 2027

Conditions
Chronic Kidney DiseasesAcute Kidney InjuryBleedingSurgery
Interventions
DRUG

Desmopressin Injectable Solution

Intravenous desmopressin, 20 mcg, single dose administration.

DRUG

Tranexamic Acid Injectable Product

Intravenous tranexamic acid, 1000 mg single dose administration for patients with eGFR\<25 not yet receiving dialysis OR 500 mg single dose administration for patients receiving dialysis.

OTHER

Placebo

Intravenous 0.9% saline solution

Trial Locations (1)

N6A 5A5

RECRUITING

London Health Sciences Centre, London

Sponsors
All Listed Sponsors
collaborator

Population Health Research Institute

OTHER

lead

Hamilton Health Sciences Corporation

OTHER