Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia

PHASE3RecruitingINTERVENTIONAL
Enrollment

290

Participants

Timeline

Start Date

June 28, 2024

Primary Completion Date

May 31, 2025

Study Completion Date

June 30, 2025

Conditions
Staphylococcus Aureus Bacteremia
Interventions
DRUG

Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid

"The choice of study drug will depend on the susceptibility of the respective isolate, expected drug interactions, contraindications, and expected side effects.~Investigators will assess whether the first-choice regimen can be given and then consider the alternative regimen. The antibiotics can be switched from first choice to the respective alternative medications during the intervention period if clinically necessary. The route of administration must be maintained according to the randomized group."

DRUG

IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline

"The choice of study drug will depend on the susceptibility of the respective isolate, expected drug interactions, contraindications, and expected side effects.~Investigators will assess whether the first-choice regimen can be given and then consider the alternative regimen. The antibiotics can be switched from first choice to the respective alternative medications during the intervention period if clinically necessary. The route of administration must be maintained according to the randomized group."

Trial Locations (12)

10450

RECRUITING

Hospital Pulau Pinang, George Town

13700

RECRUITING

Hospital Seberang Jaya, Seberang Jaya

30450

RECRUITING

Hospital Raja Permaisuri Bainun, Ipoh

41200

RECRUITING

Hospital Tengku Ampuan Rahimah, Klang

43000

RECRUITING

Hospital Sultan Idris Shah Serdang, Kajang

68000

RECRUITING

Hospital Ampang, Ampang

68100

RECRUITING

Hospital Selayang, Selayang Baru Utara

70300

RECRUITING

Hospital Tuanku Ja'afar, Seremban

75400

RECRUITING

Hospital Melaka, Malacca

80100

RECRUITING

Hospital Sultanah Aminah, Johor Bahru

05460

RECRUITING

Hospital Sultanah Bahiyah, Alor Star

08000

RECRUITING

Hospital Sultan Abdul Halim, Sungai Petani

All Listed Sponsors
lead

Clinical Research Centre, Malaysia

OTHER