10
Participants
Start Date
August 23, 2024
Primary Completion Date
March 30, 2026
Study Completion Date
March 30, 2027
CD19 t-haNK
"CD19t-haNK erived from the parental NK-92 (aNK) cell line, CD19 t-haNK is a human, allogeneic, NK cell line that has been engineered to express a CAR targeting CD19. Similar to the haNK cell line, CD19 t haNK has also been engineered to produce endoplasmic reticulum-retained IL 2 and the high-affinity (158V) variant of the Fcγ receptor (FcγRIIIa/CD16a), and thereby has enhanced CD16-targeted ADCC capabilities. CD19 t-haNK is similar to PD L1 t-haNK, differing only in the CAR that is expressed (CD19 vs PD-L1).~Rituximab is a genetically engineered chimeric murine/human monoclonal IgG1 kappa antibody directed against the CD20 antigen. Rituximab has an approximate molecular weight of 145 kD and has a binding affinity for the CD20 antigen of approximately 8.0 nM."
RECRUITING
Dr. Jackie Thomson Inc., Johannesburg
RECRUITING
FARMOVS, Bloemfonteun
RECRUITING
Albert Cellular Therapy, Pretoria
Lead Sponsor
ImmunityBio, Inc.
INDUSTRY