Study for Subjects with Relapsed/Refractory Non-Hodgkin Lymphoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

August 23, 2024

Primary Completion Date

March 30, 2026

Study Completion Date

March 30, 2027

Conditions
Non-Hodgkin Lymphoma Refractory/ Relapsed
Interventions
BIOLOGICAL

CD19 t-haNK

"CD19t-haNK erived from the parental NK-92 (aNK) cell line, CD19 t-haNK is a human, allogeneic, NK cell line that has been engineered to express a CAR targeting CD19. Similar to the haNK cell line, CD19 t haNK has also been engineered to produce endoplasmic reticulum-retained IL 2 and the high-affinity (158V) variant of the Fcγ receptor (FcγRIIIa/CD16a), and thereby has enhanced CD16-targeted ADCC capabilities. CD19 t-haNK is similar to PD L1 t-haNK, differing only in the CAR that is expressed (CD19 vs PD-L1).~Rituximab is a genetically engineered chimeric murine/human monoclonal IgG1 kappa antibody directed against the CD20 antigen. Rituximab has an approximate molecular weight of 145 kD and has a binding affinity for the CD20 antigen of approximately 8.0 nM."

Trial Locations (3)

2193

RECRUITING

Dr. Jackie Thomson Inc., Johannesburg

9301

RECRUITING

FARMOVS, Bloemfonteun

0044

RECRUITING

Albert Cellular Therapy, Pretoria

Sponsors

Lead Sponsor

All Listed Sponsors
lead

ImmunityBio, Inc.

INDUSTRY

NCT06334991 - Study for Subjects with Relapsed/Refractory Non-Hodgkin Lymphoma | Biotech Hunter | Biotech Hunter