NCT06331559 - Study of SIM0501 Alone and in Combination in Patients With Advanced Solid Tumors | Biotech Hunter

Enrollment

176

Participants

Timeline

Start Date

March 19, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2027

Conditions

Advanced Solid Tumors

Interventions

DRUG

SIM0501 Tablets

Every 28 days is one cycle. Multiple dose levels of SIM0501 will be explored in dose escalation, and determine the maximum tolerated dose.

DRUG

SIM0501 Tablets

Every 28 days is one cycle.Patients will be administered a potential recommended dose of SIM0501 established from SIM0501 mono dose escalation.

DRUG

SIM0501 in combination with olaparib

Every 28 days is one cycle.Multiple dose levels of SIM0501 and olaparib will be explored in dose escalation, and determine the maximum tolerated dose.

DRUG

SIM0501 in combination with olaparib

Every 28 days is one cycle.Patients will be administered a potential recommended dose of SIM0501 combination with olaparib established from SIM0501 combination dose escalation.

Trial Locations (1)

250117

RECRUITING

Shandong Cancer Hospital, Jinan