30
Participants
Start Date
April 17, 2024
Primary Completion Date
April 25, 2026
Study Completion Date
April 25, 2027
TCR reserved and Power3 (SPPL3) gene knock-out allogeneic CD19-targeting CAR-T cell (ATHENA-2 CAR-T)
Phase 1 dose escalation (3+3): dose 1 (1 × 10\^6 cells/kg), dose 2 (3 × 10\^6 cells/kg), dose 3 (6 × 10\^6 cells/kg); Phase 2: dose of RP2D.
Fludarabine
Intravenous fludarabine 30\~50 mg/m\^2/day on days -5, -4, and -3.
Cyclophosphamide
Intravenous cyclophosphamide 500\~1000 mg/m\^2/day on days -5, -4, and -3.
RECRUITING
Biotherapeutic Department of Chinese PLA General Hospital, Beijing
RECRUITING
Biotherapeutic Department of Chinese PLA General Hospital, Beijing
RECRUITING
School of Life Sciences, Peking University, Beijing
Chinese PLA General Hospital
OTHER