TCR Reserved and Power3 (SPPL3) Gene Knock-out Allogeneic CD19-targeting CAR-T Cell Therapy in r/r B Cell Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 17, 2024

Primary Completion Date

April 25, 2026

Study Completion Date

April 25, 2027

Conditions
Non-hodgkin Lymphoma
Interventions
BIOLOGICAL

TCR reserved and Power3 (SPPL3) gene knock-out allogeneic CD19-targeting CAR-T cell (ATHENA-2 CAR-T)

Phase 1 dose escalation (3+3): dose 1 (1 × 10\^6 cells/kg), dose 2 (3 × 10\^6 cells/kg), dose 3 (6 × 10\^6 cells/kg); Phase 2: dose of RP2D.

DRUG

Fludarabine

Intravenous fludarabine 30\~50 mg/m\^2/day on days -5, -4, and -3.

DRUG

Cyclophosphamide

Intravenous cyclophosphamide 500\~1000 mg/m\^2/day on days -5, -4, and -3.

Trial Locations (3)

100853

RECRUITING

Biotherapeutic Department of Chinese PLA General Hospital, Beijing

Unknown

RECRUITING

Biotherapeutic Department of Chinese PLA General Hospital, Beijing

RECRUITING

School of Life Sciences, Peking University, Beijing

All Listed Sponsors
lead

Chinese PLA General Hospital

OTHER