30
Participants
Start Date
March 20, 2024
Primary Completion Date
March 20, 2026
Study Completion Date
March 20, 2027
Allogeneic CD19-STAR T cell
Phase 1 dose escalation (3+3): dose 1 (2×10\^6 cells/kg), dose 2 (6×10\^6 cells/kg), dose 3 (1.8×10\^7 cells/kg); Phase 2: dose of RP2D. No more than 5 × 10\^4 per kilogram of allogenic residual TCR-positive T cells harbouring in grafts can only be released for recipient infusion.
Fludarabine
Intravenous fludarabine 30-50 mg/m\^2/day on days -5, -4, and -3.
Cyclophosphamide
Intravenous cyclophosphamide 500-1000 mg/m\^2/day on days -5, -4, and -3.
RECRUITING
Biotherapeutic Department of Chinese PLA General Hospital, Beijing
RECRUITING
School of medicine, Tsinghua University & Changping Laboratory, Beijing
Chinese PLA General Hospital
OTHER