Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

August 31, 2030

Study Completion Date

August 31, 2030

Conditions
Familial Adenomatous Polyposis
Interventions
DRUG

Rapamycin

This is a 2-dose rapamycin safety study, with a target through level of 3 to \<5 ng/ml for the first 3 months and 5-8 ng/ml for the next 3 months for each of the included patients. To avoid the possible cumulative effect, the two treatment phases will be separated by a 3-weeks wash-out period.

Trial Locations (4)

31300

CHU Toulouse Hôpital des Enfants, Toulouse

33076

CHU Bordeaux Hôpital Pellegrin, Bordeaux

34295

CHU Montpellier Hôpital Arnaud de Villeneuve, Montpellier

75019

APHP Hôpital Robert Debré, Paris

All Listed Sponsors
lead

University Hospital, Toulouse

OTHER