Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

January 2, 2024

Primary Completion Date

August 31, 2026

Study Completion Date

November 30, 2026

Conditions
Complex Regional Pain SyndromeChronic PainCausalgiaComplex Regional Pain Syndrome Type IComplex Regional Pain Syndrome Type II
Interventions
DRUG

Low dose naltrexone

While naltrexone is FDA-approved for treatment of alcohol or opioid addition, this study will be looking at how naltrexone, when dosed very low, may reduce the painful symptoms associated with CRPS. Naltrexone is not FDA-approved for pain management treatment of CRPS at this time, and therefore the study intervention is using the drug in an off-label manner.

DRUG

Placebo sugar capsules

The external appearance of the capsules prepared by the pharmacy will be identical to the LDN capsules. The inactive capsule ingredients will be microcrystalline cellulose (MCC) and Magnesium stearate

Trial Locations (1)

10021

Hospital for Special Surgery, New York

All Listed Sponsors
lead

Hospital for Special Surgery, New York

OTHER