428
Participants
Start Date
October 31, 2023
Primary Completion Date
September 30, 2025
Study Completion Date
June 30, 2026
Lidocaine
"Lidocaine group receive a loading dose of 1.5 mg/kg 2% lidocaine at anesthesia induction, followed by continuous intravenous infusion at 1.5 mg/kg/h until 24 hours postoperatively and Control group receive an equivalent volume of normal saline at anesthesia induction and throughout the perioperative period until 24 hours postoperatively.~Both groups will receive the same anesthesia and postoperative analgesia protocols, lung-protective ventilation strategy, and fluid, transfusion, and warming strategies. The only difference is the intervention during surgery, with the lidocaine group receiving continuous intravenous lidocaine."
Placebo
atients receive an equivalent volume of normal saline at anesthesia induction and throughout the perioperative period until 24 hours postoperatively.
Zhongshan Hospital,Fudan university, Shanghai
Tianjin Medical University General Hospital
OTHER
The Affiliated Hospital of Xuzhou Medical University
OTHER
West China Hospital
OTHER
Shanghai Zhongshan Hospital
OTHER