Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

May 30, 2025

Primary Completion Date

October 31, 2027

Study Completion Date

May 31, 2029

Conditions
Bellini CarcinomaCollecting Duct CarcinomaRenal Medullary Carcinoma
Interventions
DRUG

Pembrolizumab + Enfortumab Vedotin

"* Pembrolizumab will be given for a maximum of 2 years i.e. a total of 35 cycles of pembrolizumab with the q3 week dosing. Participants who complete study intervention after 2 years of pembrolizumab are eligible for up to 1 year of additional pembrolizumab (second course) upon experiencing disease progression.~* Enfortumab Vedotin will be given for a maximum of 3 cycles on day 1 and day 3 each 3 weeks. EV treatment could be re-started in case of Progressive Disease RECIST v1.1 during pembrolizumab monotherapy treatment."

Trial Locations (1)

20133

RECRUITING

Fondazione Irccs Istituto Dei Tumori Di Milano, Milan

All Listed Sponsors
lead

Giuseppe Procopio

OTHER

NCT06302569 - Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma | Biotech Hunter | Biotech Hunter