Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia.

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

March 1, 2025

Study Completion Date

March 1, 2025

Conditions
Labor Pain
Interventions
DRUG

Chlorprocaine

we aim to examine whether selective nociceptive analgesia can be obtained in epidural analgesia for women in labor by using a combination of lidocaine (opens TPRV-1 and TPRA-1 channels) and chlorprocaine (polarized local anesthetic)

DRUG

Lidocaine

Study participants will receive lidocaine alone

DRUG

Lidocaine-chlorprocaine combination

study participants randomized to this study arm will receive a a 50:50 mixture of both drugs - where all drugs are administered in concentrations based on their ED50 doses, together with epidural opioids (fentanyl)

Trial Locations (1)

91120

Hadassah Hebrew University Medical Center, POB 12000, Jerusalem

All Listed Sponsors
lead

Hadassah Medical Organization

OTHER

NCT06302257 - Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia. | Biotech Hunter | Biotech Hunter