MRD Response-adapted Allo-HSCT for Adverse-risk AML

NARecruitingINTERVENTIONAL
Enrollment

178

Participants

Timeline

Start Date

May 24, 2024

Primary Completion Date

May 1, 2027

Study Completion Date

May 1, 2028

Conditions
Acute Myeloid Leukemia
Interventions
OTHER

Intervention group

"Patients in interventional group could choose one of the following treatment protocols and then receive allo-HSCT if they were CR after the second consolidation:~1. . Venetoclax plus azacitidine: azacitidine 75mg/m2/d d1-7; venetoclax 400mg/d, d1-21;~2. . Venetoclax plus CAG: venetoclax 400mg qd d1-14; aclacinomycin 20mg qd d1-4; cytarabine 10mg/m2 q12h subcutaneous injection d1-14; G-CSF 300μg qd d1-14;~3. . Venetoclax plus IA: venetoclax 400mg qd d1-4; idarubicin 10mg qd d1-4; cytarabine 500mg qd d1-4;~4. . Venetoclax plus AA: venetoclax 400mg qd d1-7; aclacinomycin 20mg qd d1-7; cytarabine 100mg/m2 qd d1-7."

OTHER

Control group

Receive allo-HSCT directly without the second consolidation chemotherapy.

Trial Locations (1)

Unknown

RECRUITING

Peking University People's Hospital, Beijing

All Listed Sponsors
collaborator

Ruijin Hospital

OTHER

collaborator

Wuhan TongJi Hospital

OTHER

collaborator

Anhui Provincial Hospital

OTHER_GOV

lead

Peking University People's Hospital

OTHER