Safety and Efficacy of Venetoclax Combination With Decitabine(DEC3-VEN) in the Treatment of AML in the Adult

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

March 1, 2026

Study Completion Date

March 1, 2026

Conditions
Acute Myeloid Leukemia, Adult
Interventions
PROCEDURE

DEC3-VEN

Venetoclax in combination with decitabine (+-sorafenib) Venetoclax (VEN) 100mg d1, 200mg d2, 400mg d3-14 Decitabine (DEC) 20mg/m2/q8h, d4-6 (infusion time \>2h) Sorafenib 800mg/d, d8-14 (only for FLT3/ITD mutation positive patients)

Trial Locations (1)

Unknown

The Second Affiliated Hospital of Kunming Medical University., Kunming

All Listed Sponsors
collaborator

Chinese Academy of Medical Sciences

OTHER

collaborator

Handan Central Hospital

OTHER

collaborator

Taian City Central Hospital

OTHER

collaborator

Tianjin People's Hospital

OTHER

collaborator

Guizhou Provincial People's Hospital

OTHER

collaborator

Central South University

OTHER

collaborator

Western Theater General Hospital

UNKNOWN

collaborator

First Affiliated Hospital of Guangxi Medical University

OTHER

collaborator

Chengdu Jingdongfang Hospital

UNKNOWN

lead

The Second Affiliated Hospital of Kunming Medical University

OTHER

NCT06285136 - Safety and Efficacy of Venetoclax Combination With Decitabine(DEC3-VEN) in the Treatment of AML in the Adult | Biotech Hunter | Biotech Hunter