50
Participants
Start Date
November 23, 2023
Primary Completion Date
May 31, 2025
Study Completion Date
December 31, 2029
Elranatamab (PF-06863135)
The scheme of administration includes weekly administrations for at least six 4-weeks cycles and, if patients have achieved at least PR (or better) persisting for at least 2 months, the dose interval should be changed from weekly to every other week. Treatment will be scheduled with a response-adapted duration and patients achieving undetectable measurable residual disease (MRD) and maintained for 12 months will stop therapy. After stopping therapy, and if the patient is in sustained undetectable MRD for at least 12 months, it would be possible to re-start treatment with elranatamab in case the MRD will be detectable or relapse from CR will occur. Patients who will not achieve undetectable MRD sustained for 12 months will receive continuous treatment until progressive disease.
NOT_YET_RECRUITING
Hospital Universitario de Jerez de la Frontera, Jerez de la Frontera
NOT_YET_RECRUITING
Hospital Clínico Universitario de Santiago ~ CHUS, Santiago de Compostela
NOT_YET_RECRUITING
Instituto de Investigación Sanitaria Hospital 12 de Octubre, Madrid
NOT_YET_RECRUITING
Hospital HM Sanchinarro, PAU de Sanchinarro
NOT_YET_RECRUITING
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar
NOT_YET_RECRUITING
Clinica Universidad Navarra (CUN), Pamplona
RECRUITING
Hospital de Cabueñes, Gijón
NOT_YET_RECRUITING
CHU de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria
RECRUITING
Hospital Clínico Universitario Salamanca, Salamanca
NOT_YET_RECRUITING
Hospital Universitario Marqués de Valdecilla, Santander
NOT_YET_RECRUITING
C.H. de Toledo (Virgen de la Salud), Toledo
NOT_YET_RECRUITING
Hospital Son Llàtzer, Palma de Mallorca
NOT_YET_RECRUITING
Institut Catala d'Oncologia (ICO) Badalona - Hospital Universitari Germans Trias i Pujol, Badalona
NOT_YET_RECRUITING
Institut Catala d'Oncologia (ICO) Hospital Duran i Reynals, L'Hospitalet de Llobregat
NOT_YET_RECRUITING
H. Clínic i Provincial de Barcelona, Barcelona
PETHEMA Foundation
OTHER