H. Pylori Screen-and-treat Study in a Population of Young Adults

RecruitingOBSERVATIONAL
Enrollment

6,800

Participants

Timeline

Start Date

March 4, 2024

Primary Completion Date

October 1, 2026

Study Completion Date

December 1, 2026

Conditions
Gastric CancerH Pylori InfectionH Pylori EradicationH-pylori
Interventions
DRUG

Bismuth-based quadruple therapy

"Participants who are positive with H. pylori will receive bismuth-based quadruple therapy:~Antibiotic 1 - Amoxicillin 4 x 500 mg or Clarithromycin 2 x 400 mg, Antibiotic 2 - Metronidazole 4 x 400 mg, Proton pump inhibitor - Esomeprazole 2 x 40 mg, Colloidal bismuth - Bismuth oxide 4 x 120 mg."

DRUG

Levofloxacin-based quadruple therapy

"In case there will be a treatment failure after Protocol I is completed, the remaining patients with a positive infection will be referred to a secondary treatment:~Antibiotic 1 - Levofloxacin 1 x 500 mg, Antibiotic 2 - Metronidazole 4 x 400 mg, Proton pump inhibitor - Esomeprazole 2 x 40 mg, Colloidal bismuth - Bismuth oxide 4 x 120 mg."

DRUG

Standard triple therapy

"Participants who are positive for H. pylori will receive a standard triple therapy:~Antibiotic 1 - Amoxicillin 2 x 1000 mg, Antibiotic 2 - Clarithromycin 2 x 500 mg, Proton pump inhibitor - Esomeprazole 2 x 40 mg."

DRUG

Levofloxacin-based triple

"Participants with treatment failure will be recommended second line treatment - levofloxacin-based:~Antibiotic 1 - Levofloxacin 2 x 500 mg, Antibiotic 2 - Amoxicillin 2 x 1000 mg, Proton pump inhibitor - Esomeprazole 2 x 40 mg"

Trial Locations (7)

1000

RECRUITING

National Institute of Public Health, Slovenia, Ljubljana

10000

RECRUITING

University Hospital Centre Zagreb, Zagreb

51000

RECRUITING

Clinical Hospital Center Rijeka, Rijeka

400003

RECRUITING

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

D18 AK68

RECRUITING

Beacon Hospital, Dublin

LV1079

NOT_YET_RECRUITING

Clinical and Preventive Medicine of the University of Latvia, Riga

50-367

RECRUITING

Wroclaw Medical University, Wroclaw

All Listed Sponsors
collaborator

Clinical Hospital Center Rijeka

OTHER

collaborator

Clinical Hospital Centre Zagreb

OTHER

collaborator

Beacon Hospital

OTHER

collaborator

Wroclaw Medical University

OTHER

collaborator

Iuliu Hatieganu University of Medicine and Pharmacy

OTHER

collaborator

National Institute of Public Health, Slovenia

OTHER_GOV

lead

University of Latvia

OTHER