Treatment of Topical Ketorolac Gel in Acute Gouty Flare

Single intravenous administration of Ketorolac Tromethamine injection in Cohort 1 on day 1

Three doses of topical ketorolac tromethamine over the course of 1 day, 6 hours apart for each of 3 subsequent treatment periods in cohort 1 Three doses of Ketorolac Tromethamine, 6 hours apart, over the course of 5 days in cohorts 2 and 3