Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

375

Participants

Timeline

Start Date

February 29, 2024

Primary Completion Date

April 2, 2025

Study Completion Date

December 19, 2025

Conditions
High Cardiovascular RiskHypertension
Interventions
DRUG

Zilebesiran

Zilebesiran administered by subcutaneous (SC) injection

DRUG

Placebo

Placebo administered by SC injection

Trial Locations (193)

6000

Clinical Trial Site, Lucerne

10017

Clinical Trial Site, New York

17074

Clinical Trial Site, Camp Hill

18017

Clinical Trial Site, Bethlehem

19047

Clinical Trial Site, Langhorne

19114

Clinical Trial Site, Philadelphia

20011

Clinical Trial Site, Washington D.C.

20109

Clinical Trial Site, Manassas

22015

Clinical Trial Site, Burke

23510

Clinical Trial Site, Norfolk

27103

Clinical Trial Site, Winston-Salem

27401

Clinical Trial Site, Greensboro

27609

Clinical Trial Site, Raleigh

27704

Clinical Trial Site, Durham

27710

Clinical Trial Site, Durham

27834

Clinical Trial Site, Greenville

28210

Clinical Trial Site, Charlotte

28403

Clinical Trial Site, Wilmington

29572

Clinical Trial Site, Myrtle Beach

30101

Clinical Trial Site, Acworth

30134

Clinical Trial Site, Douglasville

30322

Clinical Trial Site, Atlanta

30501

Clinical Trial Site, Gainesville

31406

Clinical Trial Site, Savannah

31792

Clinical Trial Site, Thomasville

31904

Clinical Trial Site, Columbus

32055

Clinical Trial Site, Lake City

32117

Clinical Trial Site, Daytona Beach

32162

Clinical Trial Site, The Villages

32204

Clinical Trial Site, Jacksonville

32209

Clinical Trial Site, Jacksonville

32256

Clinical Trial Site, Jacksonville

32801

Clinical Trial Site, Orlando

33021

Clinical Trial Site, Hollywood

33027

Clinical Trial Site, Pembroke Pines

33126

Clinical Trial Site, Miami

33134

Clinical Trial Site, New Orleans

33135

Clinical Trial Site, Miami

33144

Clinical Trial Site, Miami

33155

Clinical Trial Site, Miami

33169

Clinical Trial Site, North Miami Beach

33176

Clinical Trial Site, Miami

33770

Clinical Trial Site, Clearwater

33880

Clinical Trial Site, Winter Haven

33901

Clinical Trial Site, Fort Myers

34957

Clinical Trial Site, Jensen Beach

35010

Clinical Trial Site, Alexander City

35801

Clinical Trial Site, Huntsville

35805

Clinical Trial Site, Huntsville

36117

Clinical Trial Site, Montgomery

36535

Clinical Trial Site, Foley

36606

Clinical Trial Site, Daphne

37027

Clinical Trial Site, Knoxville

37408

Clinical Trial Site, Chattanooga

37909

Clinical Trial Site, Knoxville

38138

Clinical Trial Site, Germantown

38671

Clinical Trial Site, Memphis

38801

Clinical Trial Site, Tupelo

39705

Clinical Trial Site, Columbus

42303

Clinical Trial Site, Owensboro

Clinical Trial Site, Monroe

43302

Clinical Trial Site, Marion

44106

Clinical Trial Site, Cleveland

46514

Clinical Trial Site, Elkhart

47374

Clinical Trial Site, Richmond

47714

Clinical Trial Site, Evansville

48066

Clinical Trial Site, Roseville

48197

Clinical Trial Site, Ypsilanti

48504

Clinical Trial Site, Flint

53227

Clinical Trial Site, Wauwatosa

55404

Clinical Trial Site, Edina

55423

Clinical Trial Site, Minneapolis

57701

Clinical Trial Site, Rapid City

59901

Clinical Trial Site, Kalispell

60602

Clinical Trial Site, Chicago

63141

Clinical Trial Site, St Louis

67042

Clinical Trial Site, El Dorado

67114

Clinical Trial Site, Newton

67207

Clinical Trial Site, Wichita

68114

Clinical Trial Site, Omaha

68510

Clinical Trial Site, Lincoln

71201

Clinical Trial Site, Monroe

73072

Clinical Trial Site, Norman

73102

Clinical Trial Site, Oklahoma City

75019

Clinical Trial Site, Coppell

75092

Clinical Trial Site, Sherman

75230

Clinical Trial Site, Dallas

75234

Clinical Trial Site, Dallas

76401

Clinical Trial Site, Stephenville

77002

Clinical Trial Site, Houston

77024

Clinical Trial Site, Houston

77054

Clinical Trial Site, Houston

77081

Clinical Trial Site, Houston

77099

Clinical Trial Site, Houston

77372

Clinical Trial Site, Splendora

77375

Clinical Trial Site 1 - Tomball, Tomball

Clinical Trial Site 2 - Tomball, Tomball

77384

Clinical Trial Site, Shenandoah

78229

Clinical Trial Site, San Antonio

78240

Clinical Trial Site, San Antonio

78744

Clinical Trial Site, Austin

79925

Clinical Trial Site, El Paso

79935

Clinical Trial Site, El Paso

79936

Clinical Trial Site, El Paso

80110

Clinical Trial Site, Denver

80230

Clinical Trial Site, Denver

80918

Clinical Trial Site, Colorado Springs

83706

Clinical Trial Site, Boise

85028

Clinical Trial Site, Phoenix

85283

Clinical Trial Site, Tempe

85297

Clinical Trial Site, Gilbert

85351

Clinical Trial Site, Sun City

85741

Clinical Trial Site, Tucson

87109

Clinical Trial Site, Albuquerque

89121

Clinical Trial Site, Coral Gables

Clinical Trial Site, Las Vegas

90022

Clinical Trial Site, Los Angeles

90057

Clinical Trial Site, Santa Ana

90211

Clinical Trial Site, Beverly Hills

91105

Clinical Trial Site, Pasadena

91307

Clinical Trial Site, West Hills

91324

Clinical Trial Site, Northridge

91405

Clinical Trial Site, Van Nuys

91723

Clinical Trial Site, Covina

Clinical Trial Site, Northridge

91773

Clinical Trial Site, San Dimas

92024

Clinical Trial Site, Encinitas

92108

Clinical Trial Site, San Diego

92111

Clinical Trial Site, San Diego

92647

Clinical Trial Site, Huntington Beach

92844

Clinical Trial Site, Garden Grove

93065

Clinical Trial Site, Simi Valley

95687

Clinical Trial Site, Vacaville

06112

Clinical Trial Site, Hartford

06762

Clinical Trial Site, Middlebury

06708

Clinical Trial Site, Waterbury

02114

Clinical Trial Site, Boston

01089

Clinical Trial Site, Springfield

03801

Clinical Trial Site, Portsmouth

08009

Clinical Trial Site, Berlin

02914

Clinical Trial Site, East Providence

05401

Clinical Trial Site, Burlington

Unknown

Clinical Trial Site, Bruce

Clinical Trial Site, Sydney

Clinical Trial Site, Brookvale

Clinical Trial Site, Concord

Clinical Trial Site, Kanwal

Clinical Trial Site, Kogarah

Clinical Trial Site, Sherwood

Clinical Trial Site, Sippy Downs

Clinical Trial Site, Garran

Clinical Trial Site, Perth

Clinical Trial Site, Winnipeg

Clinical Trial Site, Toronto

Clinical Trial Site, Waterloo

Clinical Trial Site, Chicoutimi

Clinical Trial Site, Greenfield Park

Clinical Trial Site, Montreal

Clinical Trial Site, Québec

Clinical Trial Site, Trois-Rivières

Clinical Trial Site, Basel

Clinical Trial Site, Geneva

Clinical Trial Site, Lausanne

Clinical Trial Site, Luton

Clinical Trial Site, Manchester

Clinical Trial Site, Leicester

Clinical Trial Site, Hexham

Clinical Trial Site, Glasgow

Clinical Trial Site, Carshalton

Clinical Trial Site, Birmingham

Clinical Trial Site, Cardriff

Clinical Trial Site, Chorley

Clinical Trial Site, Liverpool

Clinical Trial Site, Pickering

N7T 4X3

Clinical Trial Site, Sarnia

G1V 4T3

Clinical Trial Site, Toronto

Clinical Trial Site, Québec

00959

Clinical Trial Site, Bayamón

Clinical Trial Site, Ponce

LU4 0DZ

Clinical Trial Site, Luton

PL23 1DT

Clinical Trial Site, Fowey

PL14 3XA

Clinical Trial Site, Liskeard

TR1 3HD

Clinical Trial Site, Newquay

PL11 2JW

Clinical Trial Site, Torpoint

S40 4AA

Clinical Trial Site, Chesterfield

PL5 3JB

Clinical Trial Site, Plymouth

BS2 8ED

Clinical Trial Site, Bristol

CT1 3NG

Clinical Trial Site, Canterbury

ML4 3NJ

Clinical Trial Site, Bellshill

G11 5JT

Clinical Trial Site, Glasgow

EC1M 6BQ

Clinical Trial Site, London

SE1 1YR

Clinical Trial Site, London

SW17 0RE

Clinical Trial Site, London

Sponsors
All Listed Sponsors
lead

Alnylam Pharmaceuticals

INDUSTRY