Patient Derived Organoid-guided Personalized Treatment Versus Treatment of Physician's Choice in Breast Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

302

Participants

Timeline

Start Date

January 15, 2024

Primary Completion Date

February 15, 2026

Study Completion Date

January 15, 2028

Conditions
Breast CancerRefractory Breast Carcinoma
Interventions
OTHER

Organoid-guided personalized treatment

After the organoid culture is successful, the personalized drug library customized by our team will be used for screening. Sensitive drugs are selected based on the results of drug screening, and the most appropriate personalized treatment plan is selected based on NCCN guideline recommendations, drug safety, and conventional drugs used in the treatment of breast cancer. The personalized drug library customized by our team contains 55 drugs approved by the FDA. For specific usage, dosage and time intervals, please refer to the instructions of the corresponding drug.

DRUG

Gemcitabine

1000mg/m2,IV, days 1, 8, q3w

DRUG

Capecitabine

1000mg/m² , PO, bid, days1-14, q3w

DRUG

Vinorelbine

25mg/m2, IV or 60mg/m² (oral), days 1 and 8, q3w

DRUG

Eribulin

1.4mg/m², IV, days 1 and 8, q3w

Trial Locations (1)

510060

RECRUITING

Yanxia Shi, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER