Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect

PHASE1RecruitingINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

February 7, 2024

Primary Completion Date

March 25, 2026

Study Completion Date

March 25, 2026

Conditions
Idiopathic Pulmonary Fibrosis
Interventions
DRUG

EGCG 300 mg

"Participants will be administered EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect."

DRUG

Placebo for EGCG 300 mg

"Participants will be administered placebo for EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect."

DRUG

EGCG 600 mg

"Participants will be administered placebo for EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect."

DRUG

Placebo for EGCG 600 mg

"Participants will be administered placebo for EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect."

Trial Locations (3)

22908

NOT_YET_RECRUITING

University of Virginia, Charlottesville

48109

NOT_YET_RECRUITING

University of Michigan, Ann Arbor

02114

RECRUITING

Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Cornell University

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

University of Michigan

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Hal Chapman

OTHER