Tirofiban After Successful MT Recanalization in AIS

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

1,360

Participants

Timeline

Start Date

April 9, 2024

Primary Completion Date

January 1, 2026

Study Completion Date

January 1, 2026

Conditions
Acute Ischemic StrokeVessel Occlusion
Interventions
DRUG

Tirofiban

After the completion of endovascular treatment and successful recanalization (mTICI 2b/3), the patients were randomly assigned to the experimental group. Tirofiban 5μg/kg was administered intravenously through the catheter artery at a rate of 1ml/min, followed by an intravenous infusion of 0.1μg/(kg·min) for 24 hours. Standard medical treatment was administered after the surgery.

DRUG

Saline placebo

After the completion of endovascular treatment and successful recanalization (mTICI 2b/3), the patients were randomly assigned to the experimental group. Saline placebo was administered in the same manner as tirofiban group. Standard medical treatment was administered after the surgery.

Trial Locations (1)

450001

RECRUITING

Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan

All Listed Sponsors
collaborator

Wuhan Central Hospital

OTHER

collaborator

Zhongnan Hospital

OTHER

collaborator

Renmin Hospital of Wuhan University

OTHER

collaborator

Second Affiliated Hospital of Soochow University

OTHER

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Wuhan Hospital of Traditional Chinese Medicine

OTHER

collaborator

The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture

OTHER

collaborator

Huangshi Central Hospital

OTHER

collaborator

The First Affiliated Hospital of Yangtze University

OTHER

collaborator

The Fifth Hospital of Wuhan

OTHER

collaborator

Wuhan Puren Hospital

OTHER

collaborator

Xiangyang No.1 People's Hospital

OTHER

collaborator

Xianning Central Hospital

OTHER

collaborator

Hanyang University

OTHER

collaborator

Wuhan Third Hospital

OTHER

collaborator

Yichang Central People's Hospital

OTHER

collaborator

Affiliated Hospital of Chengde Medical University

OTHER

collaborator

Beijing Tiantan Hospital

OTHER

collaborator

Nanyang Central Hospital

OTHER

collaborator

Jingzhou Central Hospital

OTHER

collaborator

Taihe Hospital

OTHER

collaborator

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

OTHER

lead

Xiang Luo

OTHER