NCT06258525View on ClinicalTrials.gov

SAMe in Prevention of Oxaliplatin-associated Liver Injury

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

September 15, 2025

Primary Completion Date

February 15, 2028

Study Completion Date

February 15, 2028

Conditions
Colorectal CancerLiver MetastasesLiver Metastasis Colon CancerLiver InjurySinusoidal Obstruction Syndrome5-Fluorouracil ToxicityLiver Toxicity, Chemically-Induced
Interventions
RADIATION

Standard of care oxaliplatin-based chemotherapy

mFOLFOX6 or CAPOX

DIETARY_SUPPLEMENT

S-adenosylmethionine (SAMe) supplement

(400 mg tablet): 2 tablets taken orally AM and 1 tablet PM daily (total 1,200 mg daily) prior to surgical resection

PROCEDURE

Surgery

At 1-Month

Trial Locations (2)

90048

Cedars-Sinai Medical Center at SOCC, Los Angeles

90211

Cedars-Sinai Medical Center Beverly Hills, Los Angeles

All Listed Sponsors
collaborator

Jarrow Formulas Inc

INDUSTRY

lead

Cedars-Sinai Medical Center

OTHER