NCT06257004View on ClinicalTrials.gov

Genome-wide Epistasis for Cardiovascular Severity in Marfan Study

RecruitingOBSERVATIONAL
Enrollment

200

Participants

Timeline

Start Date

November 30, 2020

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2025

Conditions
Marfan SyndromeFBN1 Mutation
Interventions
GENETIC

Saliva collection (screening of all participants)

All participants will give a salive sample (self-sampling kit) - selection of 25% extremes (UMC and AMC) participants for WGS and linkage analysis

GENETIC

Bloodsampling

Based on the results of the WGS, a selection will be made of the 5% most extremes (UMC and AMC) participants for the iPSC-VSMC generation

Trial Locations (1)

2650

RECRUITING

University Hospital Antwerp, Edegem

All Listed Sponsors
collaborator

University Hospital, Ghent

OTHER

lead

University Hospital, Antwerp

OTHER