Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety

NARecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

March 1, 2022

Primary Completion Date

February 28, 2030

Study Completion Date

February 28, 2030

Conditions
Peanut AllergyMilk Allergy, Cow'sEgg Allergy
Interventions
OTHER

Food allergy desensitization / Oral Immunotherapy

"Participants consume increasing doses of allergenic food daily until they reach a maintenance dose. In the case of the High Dose Arm, participants will progress to a daily dose of either 1200 mg, 300 mg or 200 ml of egg, peanut or milk respectively.~Participants randomized to the Low Dose Arm also begin by consuming small amounts of the allergenic food, gradually increasing the daily dose. However, participants in this group only progress to 300 ml, 30 mg or 50 ml daily dose of egg, peanut or milk respectively.~The Cooked/Transformed Allergen Arm begins the desensitization with a cooked or transformed form of the allergen - muffins in the case of egg or milk, Bamba puffs in the case of peanut. Participants take increasing amounts of these products (one muffin for egg and milk and four Bamba puffs for peanut) then transition to egg, milk or peanut. Participants then continue their dose progression, getting to 1200 mg, 200 ml or 300 mg for egg, milk and peanut respectively."

Trial Locations (1)

H4A 3J1

RECRUITING

Research Institute of the McGill University Health Centre, Montreal

All Listed Sponsors
collaborator

The Hospital for Sick Children

OTHER

lead

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER