Dose, Safety, and Pathogenicity of a New Influenza B Strain

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

October 3, 2023

Primary Completion Date

February 2, 2024

Study Completion Date

February 8, 2024

Conditions
Influenza B
Interventions
BIOLOGICAL

influenza B/Connecticut/1/21 virus part a dose arm 1

Medium dose, expected to be approximately 10\^6 tissue culture infective dose 50% (TCID50)/mL (titer may be adjusted based on stock titer)

BIOLOGICAL

influenza B/Connecticut/1/21 virus part a dose arm 2

High dose, expected to be approximately 10\^7 TCID50/ mL (titer may be adjusted based on stock titer)

BIOLOGICAL

influenza B/Connecticut/1/21 virus part b dose 1

Extension of one of the Part A dose arms; which one is to be determined (TBD) depending on outcome of Part A, AND/OR Dose Arm 3

BIOLOGICAL

influenza B/Connecticut/1/21 virus part b dose 2

Addition of a 3rd dose, TBD depending on outcome of Part A

Trial Locations (1)

E1 2AX

RECRUITING

QMB, London

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Hvivo

INDUSTRY