102
Participants
Start Date
January 1, 2024
Primary Completion Date
November 1, 2026
Study Completion Date
December 1, 2026
Pyrotinib dose escalation
Pyrotinib: 240mg in the first week, 320mg in the second week, and 400mg in the third week and thereafter, by mouth(po),once a day(qd) Trastuzumab: 8mg/Kg in the first cycle, 6mg/Kg in the subsequent cycle, intravenous(iv), every 3 weeks(q3w) Docetaxel: 75mg/m2，intravenous(iv), every 3 weeks(q3w)
Pyrotinib dose normal
Pyrotinib: 400mg per week, by mouth(po),once a day(qd) Trastuzumab: 8mg/Kg in the first cycle, 6mg/Kg in the subsequent cycle, intravenous(iv), every 3 weeks(q3w) Docetaxel: 75mg/m2，intravenous(iv), every 3 weeks(q3w)
RECRUITING
Jiangsu Provincial People's Hospital, Nanjing
Zhongda Hospital
OTHER
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
OTHER
Jingjiang People's Hospital
OTHER
Yancheng First People's Hospital
OTHER
Affiliated Hospital of Jiangnan University
OTHER
Affiliated Hospital of Nantong University
OTHER
Anhui Provincial Cancer Hospital
OTHER
Huai'an First People's Hospital
OTHER
The Affiliated Hospital of Xuzhou Medical University
OTHER
Suzhou Municipal Hospital
OTHER
Affiliated Hospital of Jiangsu University
OTHER
The First Affiliated Hospital with Nanjing Medical University
OTHER