12
Participants
Start Date
September 19, 2024
Primary Completion Date
December 31, 2027
Study Completion Date
June 30, 2028
TTRNA-DC vaccines with GM-CSF
Participants will receive up to 9 intradermal DC vaccines (three -bi-weekly (q2 weeks) for priming, monthly for additional 2-3 cycles during T cell expansion, and three bi-weekly during T cell engraftment
Autologous Hematopoietic Stem cells (HSCs)
Participants will receive a single infusion of autologous CD34+ HSCs
TTRNA-xALT
Participants will receive a single infusion of ex vivo expanded tumor-reactive T cells
Td vaccine
All patients will receive a full Td booster IM vaccine 4-24 hours prior to Vaccine #1 and vaccine site pretreatment with a one-fifth dose of Td intradermally, at the site of planned vaccine, 4-24 hours prior to vaccines #3, #5, #7 and #9.
University of Florida Health Shands Hospital, Gainesville
Oligo Nation, Inc
UNKNOWN
University of Florida
OTHER