60
Participants
Start Date
May 14, 2024
Primary Completion Date
December 31, 2026
Study Completion Date
December 31, 2028
AdHER2DC vaccine
AdHER2DC vaccine is given by intradermal injections on Day 1 of cycles 1-3 (priming) followed by optional boost doses (up to 3), on Day 1 of cycles 6, 9, 12
Pembrolizumab
Pembrolizumab is given by IV infusion on Day 8 of cycle 1 and Day 1 of cycles 2-16
N-803
N-803 is given by subcutaneous injections on Day 1 of cycles 1-16
Lenvatinib
Lenvatinib is taken orally on Days 8-28 on cycle 1 and every day of cycles 2-16
PATHWAY HER2 (4B5) assay
Used during screening to estimate eligibility
RECRUITING
National Institutes of Health Clinical Center, Bethesda
National Cancer Institute (NCI)
NIH