Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

June 11, 2024

Primary Completion Date

July 31, 2028

Study Completion Date

July 31, 2028

Conditions
Mantle Cell Lymphoma
Interventions
BIOLOGICAL

Obinutuzumab

Given intravenously (IV)

BIOLOGICAL

Glofitamab

Given IV

DRUG

Pirtobrutinib

Given Orally (PO)

PROCEDURE

Tumor Imaging

Undergo regular care imaging/scans

PROCEDURE

Biospecimen Collection

Blood and tissue samples

DEVICE

ClonoSeq Assay

ClonoSEQ is an FDA-cleared, Clinical Laboratory Improvement Amendments of 1988 (CLIA)-validated measure used to determine minimal residual disease (MRD). This helps uncover how much, if any, cancer remains in your body during and after treatment.

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy and aspiration.

Trial Locations (2)

94143

RECRUITING

University of California, San Francisco, San Francisco

95616

RECRUITING

University of California, Davis, Davis

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Adaptive Biotechnologies

INDUSTRY

lead

University of California, San Francisco

OTHER