CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

December 19, 2024

Primary Completion Date

December 11, 2026

Study Completion Date

December 11, 2026

Conditions
HIV-1
Interventions
BIOLOGICAL

CMV/HIV-CAR T Cells

Eligible participants will temporarily interrupt their ART regimen for 4 days prior to leukapheresis to prevent residual cell drug levels that could inhibit lentiviral transduction of the T cells during CAR T cewll manufacturing. Participants will resume their ART regimen immediately after leukapheresis. Once the final cell product is released, participants will receive a single intravenous (IV)infusion of autologous CMV/HIV-CAT T cells (defined as Day 0). Up to three doses of CMV/HIV-CAR T cewlls may be explored.

Trial Locations (2)

91010

RECRUITING

City of Hope Medical Center, Duarte

92093

RECRUITING

UCSD, Division of Infectious Diseases and Global Public Health, San Diego

All Listed Sponsors
lead

City of Hope Medical Center

OTHER