Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients

Dexmedetomidine is an α2-adrenergic agonist sedative commonly used in invasive mechanical ventilation that promotes patient wakefulness, has no effect on respiratory drive, has important analgesic properties, and when compared to γ-aminobutyric acid receptor agonists like benzodiazepines, reduces delirium.

Normal saline placebo will be given as continuous infusion.