Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori Infection

NACompletedINTERVENTIONAL
Enrollment

806

Participants

Timeline

Start Date

February 10, 2024

Primary Completion Date

May 10, 2024

Study Completion Date

May 10, 2024

Conditions
Helicobacter Pylori Infection
Interventions
DRUG

esomeprazole + amoxicillin

esomeprazole enteric-coated tablets (AstraZeneca) 20mg four times daily and amoxicillin capsules (Hainan General Sanyang Pharmaceutical) 750mg four times daily

DRUG

esomeprazole + amoxicillin + clarithromycin + colloidal bismuth tartrate agent

20mg twice daily of esomeprazole enteric-coated tablets, 1000 mg twice daily of amoxicillin capsules, 500 mg twice daily of clarithromycin sustained-release tablets (Henan Fusen Pharmaceutical) and 165 mg three times daily of colloidal bismuth tartrate capsules (Shanxi Xinbaoyuan Pharmaceutical)

DRUG

Vonoprazan + amoxicillin

20 mg twice daily of vonoprazan fumarate tablets (Takeda Pharmaceutical Company Limited) and 1000 mg three times daily of amoxicillin capsules (Hainan General Sanyang Pharmaceutical)

DRUG

Vonoprazan + amoxicillin + clarithromycin

20 mg twice daily of vonoprazan fumarate tablets, 1000 mg twice daily of amoxicillin capsules and 500 mg twice daily of clarithromycin sustained-release tablets (Henan Fusen Pharmaceutical)

Trial Locations (1)

410013

outpatient department of gastroenterology of the Third Xiangya Hospital of Central South University, Changsha

All Listed Sponsors
collaborator

The Second People's Hospital of Huaihua

UNKNOWN

collaborator

Yueyang Hospital of Traditional Chinese Medicine

UNKNOWN

lead

The Third Xiangya Hospital of Central South University

OTHER

NCT06250634 - Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori Infection | Biotech Hunter | Biotech Hunter