Phase 1/2 Study of HYP-2090PTSA in Patients With Advanced Solid Tumors Harboring KRAS Mutation

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

257

Participants

Timeline

Start Date

February 4, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
SafetyTolerabilityEfficacy
Interventions
DRUG

Test product: HYP-2090PTSA

"Dosage form: Capsule. Strength: 2.5 mg, 5 mg. Method of administration: Oral; Dose escalation: a fixed dose QD is planned, and all other dose levels and administration methods are temporary with the exception of the initial dose. Dose expansion: the dose and method of administration are conducted as discussed by the sponsor and investigators.~Medication cycle: Take orally under fasting condition every morning, with 21 days as a cycle (tentative), and continue taking until disease progression, or intolerable toxicity, or withdrawal of informed consent, or treatment with another antitumor drug, or the death of the subject, or loss to follow-up (whichever occurs earliest)."

Trial Locations (6)

110000

NOT_YET_RECRUITING

The first Hospital of China Medical University, Shenyang

200000

RECRUITING

Shanghai Pulmonary Hospital, Shanghai

250000

NOT_YET_RECRUITING

Shandong Provincial Cancer Hospital, Jinan

350000

RECRUITING

Fujian Provincial Cancer Hospital, Fuzhou

410000

NOT_YET_RECRUITING

Hunan Provincial Cancer Hospital, Changsha

610000

RECRUITING

West China Hospital of Sichuan University, Chengdu

All Listed Sponsors
lead

Sichuan Huiyu Pharmaceutical Co., Ltd

INDUSTRY