80
Participants
Start Date
August 9, 2021
Primary Completion Date
July 31, 2026
Study Completion Date
July 31, 2026
Levodopa
Participants will take levodopa in dosages prescribed by their care provider. Patients will be instructed to not take their regularly prescribed PD medications for 12 hours prior to the study assessment, as is typical for clinical evaluations in patients with PD. Participants will be tested in both levodopa-off (after 12 hours of not having medication) and levodopa-on states.
Clinical DBS Setting
Deep brain stimulation performed with the patients' optimized clinical setting.
Sham DBS
Deep brain stimulation performed with sham stimulation.
DBS Setting Maximizing Prefrontal Activation
Deep brain stimulation performed to maximize the activation of the prefrontal cortico-STN projections.
DBS Setting Minimizing Prefrontal Activation
Deep brain stimulation performed to minimize the activation of the prefrontal cortico-STN projections.
RECRUITING
Emory University Hospital, Atlanta
RECRUITING
Emory Brain Health Center, Atlanta
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Emory University
OTHER