Cortical Electrophysiology of Response Inhibition in Parkinson's Disease

PHASE4RecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

August 9, 2021

Primary Completion Date

July 31, 2026

Study Completion Date

July 31, 2026

Conditions
Parkinson Disease
Interventions
DRUG

Levodopa

Participants will take levodopa in dosages prescribed by their care provider. Patients will be instructed to not take their regularly prescribed PD medications for 12 hours prior to the study assessment, as is typical for clinical evaluations in patients with PD. Participants will be tested in both levodopa-off (after 12 hours of not having medication) and levodopa-on states.

DEVICE

Clinical DBS Setting

Deep brain stimulation performed with the patients' optimized clinical setting.

DEVICE

Sham DBS

Deep brain stimulation performed with sham stimulation.

DEVICE

DBS Setting Maximizing Prefrontal Activation

Deep brain stimulation performed to maximize the activation of the prefrontal cortico-STN projections.

DEVICE

DBS Setting Minimizing Prefrontal Activation

Deep brain stimulation performed to minimize the activation of the prefrontal cortico-STN projections.

Trial Locations (2)

30322

RECRUITING

Emory University Hospital, Atlanta

30329

RECRUITING

Emory Brain Health Center, Atlanta

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

Emory University

OTHER