Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

"Participants assigned to CBD will take the medication one hour before or two hours after eating a meal.~If participants can't tolerate the full-strength dose, the participant can decrease the dosing to 0.75 milliliter twice a day. If this is still not well tolerated, dosing can further be decreased to 0.75 milliliter once per day in the evening."

Participants will be instructed to take one hour before or two hours after eating a meal.