Thalidomide Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP)

PHASE2RecruitingINTERVENTIONAL
Enrollment

132

Participants

Timeline

Start Date

January 19, 2024

Primary Completion Date

June 30, 2024

Study Completion Date

September 30, 2025

Conditions
Lung Cancer, Nonsmall CellEsophageal Carcinoma
Interventions
DRUG

Camrelizumab

Camrelizumab 200mg intravenous (IV) on Day 1 of each 21-day cycle,until progression or unacceptable toxicity

DRUG

Thalidomide 50mg

Thalidomide 50mg,po qd;

DRUG

Thalidomide 100mg

Thalidomide 100mg,po qd;

DRUG

Thalidomide 200mg

Thalidomide 200mg,po qd;

DRUG

Chemotherapy

"Platinum-based chemotherapy:~1. Esophageal squamous cell carcinoma: cisplatin/carboplatin/nedaplatin/lobaplatin+ paclitaxel/albumin-bound paclitaxel/fluorouracil on Day 1 of each 21-day cycle for 4-6 cycles;~2. Non-small cell lung cancer (non-squamous cell carcinoma): pemetrexed plus carboplatin/cisplatin on Day 1 of each 21-day cycle for 4-6 cycles,pemetrexed every three weeks (Q3W) maintenance for the remainder of the study or until documented PD;~3. Non-small cell lung cancer (squamous cell carcinoma) : paclitaxel/albumin-bound paclitaxel + carboplatin/cisplatin on Day 1 of each 21-day cycle for 4-6 cycles."

Trial Locations (2)

Unknown

RECRUITING

Ying Liu, Zhengzhou

NOT_YET_RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

All Listed Sponsors
collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

lead

Henan Cancer Hospital

OTHER_GOV