Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward

PHASE3RecruitingINTERVENTIONAL
Enrollment

326

Participants

Timeline

Start Date

April 25, 2024

Primary Completion Date

May 25, 2027

Study Completion Date

May 25, 2027

Conditions
Community-acquired Pneumonia
Interventions
DRUG

Amoxicillin

"Participants will be randomized to IV/oral amoxicillin or IV/oral amoxicillin/clavulanate for 5 days. Both agents are approved for treatment of respiratory infections.~Amoxicillin PO: The dose is two capsule of 500 mg every 8 hours (that is 3 times daily).~Amoxicillin IV: The dose is 1 g every 8 hours (that is 3 times daily)"

DRUG

Amoxicillin/clavulanate

"Participants will be randomized to IV/oral amoxicillin or IV/oral amoxicillin/clavulanate for 5 days. Both agents are approved for treatment of respiratory infections.~Amoxicillin/clavulanate PO: The dose is two tablets of 500 mg/62.5 mg every 8 hours (that is 3 times daily, approved standard dose) Amoxicillin/clavulanate IV: The dose is 1 g/200 mg every 8 hours (that is 3 times daily, approved standard dose)"

Trial Locations (17)

Unknown

RECRUITING

Chu Angers, Angers

RECRUITING

CHU Angers, Angers

RECRUITING

CHU Avicenne AP-HP, Bobigny

RECRUITING

CHU Avicenne AP-HP, Bobigny

RECRUITING

CHRU Brest, Brest

RECRUITING

CHRU Brest, Brest

RECRUITING

CHD Vendée, La Roche-sur-Yon

RECRUITING

CHD Vendée, La Roche-sur-Yon

RECRUITING

CHU Grenoble-Alpes, La Tronche

RECRUITING

CHU Grenoble-Alpes, La Tronche

RECRUITING

Assistance Publique Hopitaux De Marseille, Marseille

RECRUITING

CHU de Nantes, Nantes

RECRUITING

CH Perigueux, Périgueux

RECRUITING

CHRU - TOULOUSE Hôpital Purpan, Toulouse

RECRUITING

CHRU - TOULOUSE Hôpital Purpan, Toulouse

RECRUITING

CHRU TOULOUSE - Hôpital Rangueuil, Toulouse

RECRUITING

Centre Hospitalier Bretagne Atlantique, Vannes

All Listed Sponsors
lead

Nantes University Hospital

OTHER