6
Participants
Start Date
December 1, 2023
Primary Completion Date
June 30, 2025
Study Completion Date
June 30, 2026
hNeo-T
After subject screening, peripheral blood mononuclear cell (PBMC) donors matching half or more of the subject's HLA matching will undergo blood collection to prepare hNeo-T. hNeo-T preparation is expected to be 25-30 days after blood collection. In this study, the bridging therapy will be allowed before Chemotherapy preconditioning, and the investigators will decide whether to use it. Chemotherapy preconditioning will be performed before hNeo-T transfusion. If the absolute value of lymphocyte (LYM) before pretreatment is \<0.8×10\^9/L and the subject meets the criteria for cell transfusion, the chemotherapy preconditioning will not be performed and subsequent cell transfusion can be performed directly.
Cyclophosphamide
Chemotherapy preconditioning will be performed before hNeo-T transfusion.
Fludarabine
Chemotherapy preconditioning will be performed before hNeo-T transfusion
RECRUITING
ShenZhen University General Hospital, Shenzhen
Shenzhen University General Hospital
OTHER
BGI, China
OTHER