Treatment of Relapsed or Refractory Epstein-Barr Virus Positive T-cell Lymphoma With hNeo-T

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

December 1, 2023

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2026

Conditions
T-cell Lymphoma
Interventions
BIOLOGICAL

hNeo-T

After subject screening, peripheral blood mononuclear cell (PBMC) donors matching half or more of the subject's HLA matching will undergo blood collection to prepare hNeo-T. hNeo-T preparation is expected to be 25-30 days after blood collection. In this study, the bridging therapy will be allowed before Chemotherapy preconditioning, and the investigators will decide whether to use it. Chemotherapy preconditioning will be performed before hNeo-T transfusion. If the absolute value of lymphocyte (LYM) before pretreatment is \<0.8×10\^9/L and the subject meets the criteria for cell transfusion, the chemotherapy preconditioning will not be performed and subsequent cell transfusion can be performed directly.

DRUG

Cyclophosphamide

Chemotherapy preconditioning will be performed before hNeo-T transfusion.

DRUG

Fludarabine

Chemotherapy preconditioning will be performed before hNeo-T transfusion

Trial Locations (1)

518000

RECRUITING

ShenZhen University General Hospital, Shenzhen

All Listed Sponsors
collaborator

Shenzhen University General Hospital

OTHER

lead

BGI, China

OTHER