DV Combined With Cadonilimab in Subjects With HER2-expressing Gastric Cancer and Gastroesophageal Junction Adenocarcinoma After Progression on First-line Therapy

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

February 22, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Gastric CancerGastroesophageal Junction Adenocarcinoma
Interventions
DRUG

Disitamab Vedotin Injection

Phase II and III study :2.5mg/kg, intravenous infusion,D1, every 2 weeks

DRUG

Cadonilimab Injection

Phase II and III study :6.0mg/kg, intravenous infusion,D1, every 2 weeks.

DRUG

Paclitaxel Injection

Phase II and III study :Calculate dosage based on body surface are,160mg/m2,intravenous infusion,D1,D8 every 3 weeks

Trial Locations (12)

100142

RECRUITING

Beijing Cancer Hospital, Beijing

150081

NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200025

NOT_YET_RECRUITING

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

221009

RECRUITING

Xuzhou Central Hospital, Xuzhou

250117

RECRUITING

Shandong Cancer Hospital, Jinan

266003

NOT_YET_RECRUITING

The Affiliated Hospital of Qingdao University, Qingdao

361003

NOT_YET_RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

410031

RECRUITING

Hunan Cancer Hospital, Changsha

430079

NOT_YET_RECRUITING

Hubei Cancer Hospital, Wuhan

450052

NOT_YET_RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

610041

NOT_YET_RECRUITING

West China Hospital of Sichuan University, Chengdu

650118

RECRUITING

Yunnan Cancer Hospital, Kunming

All Listed Sponsors
lead

RemeGen Co., Ltd.

INDUSTRY