Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion

PHASE3RecruitingINTERVENTIONAL
Enrollment

390

Participants

Timeline

Start Date

December 16, 2023

Primary Completion Date

December 31, 2024

Study Completion Date

May 31, 2025

Conditions
Ischemic Stroke, AcuteThrombolysisEndovascular Treatment
Interventions
DRUG

rhTNK-tPA

rhTNK-tPA (0.25 mg/kg, maximum dose 25mg) is given as a single, intravenous bolus (injection over 5 to 10 seconds) immediately upon randomization. EVT should be performed as soon as possible after rhTNK-tPA administration.

DEVICE

direct EVT

During the study period, NMPA-approved stents are permitted. EVT included thrombectomy with stent retrievers, thromboaspiration, intraarterial thrombolysis, balloon angioplasty, stenting, or a combination of these approaches at the discretion of the interventional team.

Trial Locations (10)

100070

ACTIVE_NOT_RECRUITING

Beijing Tiantan Hospital, Capital Medical University, Beijing

210002

ACTIVE_NOT_RECRUITING

Eastern Theater General Hospital, Nanjing

252006

ACTIVE_NOT_RECRUITING

Liaocheng Third People's Hospital, Liaocheng

266000

ACTIVE_NOT_RECRUITING

Qingdao Central Hospital, Qingdao

274400

ACTIVE_NOT_RECRUITING

Heze Municipal Hospital, Heze

276003

RECRUITING

Linyi People's Hospital, Linyi

276800

ACTIVE_NOT_RECRUITING

Rizhao People's Hospital, Rizhao

ACTIVE_NOT_RECRUITING

Rizhao Traditional Chinese Medicine Hospital, Rizhao

637699

ACTIVE_NOT_RECRUITING

Linfen Central Hospital, Linfen

710061

ACTIVE_NOT_RECRUITING

First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an

All Listed Sponsors
collaborator

Linyi People's Hospital

OTHER

lead

Beijing Tiantan Hospital

OTHER