A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

PHASE1RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

March 28, 2024

Primary Completion Date

July 15, 2027

Study Completion Date

July 15, 2027

Conditions
Multiple SclerosisMyasthenia Gravis
Interventions
DRUG

CC-97540

Specified dose on specified days

DRUG

Fludarabine

Specified dose on specified days

DRUG

Cyclophosphamide

Specified dose on specified days

Trial Locations (35)

2650

RECRUITING

Antwerp University Hospital, Edegem

9000

RECRUITING

UZ Gent, Ghent

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10032

RECRUITING

Neurological Institute of New York, New York

20132

WITHDRAWN

Local Institution - 0008, Milan

28034

RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

35294

RECRUITING

University of Alabama at Birmingham, Birmingham

40225

RECRUITING

Universitaetsklinikum Duesseldorf, Düsseldorf

44195

RECRUITING

Cleveland Clinic Mellen Center, Cleveland

45147

RECRUITING

Universitaetsklinikum Essen, Essen

45219

RECRUITING

University of Cincinnati Medical Center, Cincinnati

46026

RECRUITING

Hospital Universitari i Politecnic La Fe, Valencia

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

59000

RECRUITING

Hopital Claude Huriez - CHU de Lille, Lille

63110

RECRUITING

Washington University School of Medicine, St Louis

66160

RECRUITING

University of Kansas Medical Center, Kansas City

70121

WITHDRAWN

Local Institution - 0039, New Orleans

75013

RECRUITING

Pitie Salpetriere University Hospital, Paris

80045

RECRUITING

University of Colorado Anschutz Medical Campus, Aurora

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

81337

RECRUITING

Klinikum der Universität München Großhadern, München

91054

RECRUITING

Universitaetsklinikum Erlangen, Erlangen

92697

RECRUITING

University of California, Irvine, Irvine

97239

NOT_YET_RECRUITING

Local Institution - 0037, Portland

98122

RECRUITING

Swedish Medical Center, Seattle

06510

RECRUITING

Yale-New Haven Hospital, New Haven

02114

COMPLETED

Local Institution - 0005, Boston

07601

RECRUITING

Hackensack University Medical Center, Hackensack

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

NOT_YET_RECRUITING

Local Institution - 0016, Barcelona

08036

RECRUITING

Hospital Clínic de Barcelona, Barcelona

M20 2RZ

RECRUITING

Manchester Royal Infirmary, Manchester

NW1 2PG

RECRUITING

University College London Hospital, London

M6 8HD

RECRUITING

Salford Royal Hospital, Salford

E1 1RD

RECRUITING

Barts Health NHS Trust, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene Corporation

INDUSTRY

lead

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

INDUSTRY