Vasopressin for Septic Shock Pragmatic Trial

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

2,050

Participants

Timeline

Start Date

February 1, 2024

Primary Completion Date

July 31, 2026

Study Completion Date

December 31, 2027

Conditions
Septic Shock
Interventions
DRUG

Vasopressin

Intravenous vasopressin infusion added to first-line vasopressors. Recommended vasopressin dose is 1.8 units/hour (equivalent to 0.03 units/minute) at a fixed rate.

OTHER

Recommendation to use a lower initiation threshold for vasopressin

Recommended to initiate intravenous vasopressin infusion if the combined dose of other vasopressors reaches ≥0.1 mcg/kg/min of norepinephrine (or equivalent)

OTHER

Recommendation to use a higher initiation threshold for vasopressin

Recommended to initiate intravenous vasopressin infusion if the combined dose of other vasopressors reaches ≥0.4 mcg/kg/min of norepinephrine (or equivalent)

Trial Locations (13)

83318

Cassia Regional Hospital, Burley

84003

American Fork Hospital, American Fork

84041

Layton Hospital, Layton

84060

Park City Hospital, Park City

84065

Riverton Hospital, Riverton

84094

Alta View Hospital, Sandy City

84107

Intermountain Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84341

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital, Ogden

84604

Utah Valley Hospital, Provo

84721

Cedar City Hospital, Cedar City

84790

St. George Regional Hospital, St. George

All Listed Sponsors
collaborator

University of Utah

OTHER

lead

Intermountain Health Care, Inc.

OTHER

NCT06217562 - Vasopressin for Septic Shock Pragmatic Trial | Biotech Hunter | Biotech Hunter